Millsboro, Delaware is a small town at the headwaters of the Indian River. Millsboro is great for outdoor lovers watching birds, boating and fishing along the river and at the local freshwater ponds and great for those wanting to go antiquing and eating at good restaurants. Away from the hustle and bustle of the big city and large coastal resorts, though it's convenient to both larger cities and the beach, Millsboro is the perfect place to go for anyone wanting a quiet and relaxing vacation.